Dr. Julien Yann Dutheil

Molecular Systems Evolution

The Molecular Systems Evolution research group combines systems biology and molecular evolution / population genetic approaches in order to understand the mechanisms of natural selection at multiple levels. The group research involves "omics" analyses, from atoms in molecules (Structural bioinformatics) to genome in populations (Population genomics). We develop statistical models to analyse biological data in an evolutionary framework. Our current interests include (i) how structural constraints in biomolecules shape the patterns of sequence evolution and (ii) the development of new models for population genomic analysis. The group recently focused on the evolution of stochastic gene expression and the evolution of the regulome, using single-cell transcriptomics data.

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Dr. Julien Yann Dutheil

Max Planck Institute for Evolutionary Biology, Plön

Tel.: +49 (0) 4522 763-298
Email | Homepage

Selected Publications

  • Dutheil JY, et al. (2016) A Tale of Genome Compartmentalization: The Evolution of Virulence Clusters in Smut Fungi. Genome Biol Evol 8(3):681–704.
  • Dutheil JY, Munch K, Nam K, Mailund T, Schierup MH (2015) Strong Selective Sweeps on the X Chromosome in the Human-Chimpanzee Ancestor Explain Its Low Divergence. PLoS Genet 11(8):e1005451.
  • Scally A, et al. (2012) Insights into hominid evolution from the gorilla genome sequence. Nature 483(7388):169–175.
  • Dutheil JY, Jossinet F, Westhof E (2010) Base pairing constraints drive structural epistasis in ribosomal RNA sequences. Mol Biol Evol 27(8):1868–1876.
  • Dutheil JY, et al. (2009) Ancestral population genomics: the coalescent hidden Markov model approach. Genetics 183(1):259–274.