Prof. Stefan Niemann

Molecular and Experimental Mycobacteriology

Prof. Dr. Stefan Niemann is a molecular biologist with a large experience in molecular characterization of M. tuberculosis complex (Mtbc) isolates. Actual research interests are focused on the development of rapid diagnostics e.g. using next generation sequencing, the epidemiology of tuberculosis (TB), mechanisms of development and spread of resistance in clinical Mtbc isolates, the microevolution in clinical Mtbc isolates, the global population structure and evolution of the Mtbc, and on the pathobiology and host-pathogen interaction. Modern genotyping tools are used to investigate the epidemiology and evolution of TB in low and high incidence settings. His group has pioneered the use of next generation sequencing for genome analysis of MTBC isolates and established a microarray facility with new bioinformatics core unit. He has a long experience in collaborative research on national and international level.

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Prof. Stefan Niemann

Research Center Borstel

Tel.: +49 (0) 4537-188-7620

Email | homepage

Selected Publications

  • Merker M, et al. (2015) Evolutionary history and global spread of the Mycobacterium tuberculosis Beijing lineage. Nat Genet 47(3):242–249.
  • Walker TM, et al. (2015) Whole-genome sequencing for prediction of Mycobacterium tuberculosis drug susceptibility and resistance: a retrospective cohort study. The Lancet Infectious Diseases 15(10):1193–1202.
  • Sanchez-Padilla E, et al. (2015) Detection of drug-resistant tuberculosis by Xpert MTB/RIF in Swaziland. New England Journal of Medicine 372(12):1181–1182.
  • Roetzer A, et al. (2013) Whole genome sequencing versus traditional genotyping for investigation of a Mycobacterium tuberculosis outbreak: a longitudinal molecular epidemiological study. PLoS Med 10(2):e1001387.
  • Cox HS, et al. (2008) Emergence of extensive drug resistance during treatment for multidrug-resistant tuberculosis. New England Journal of Medicine 359(22):2398–2400.