Dr. Linda Odenthal-Hesse

Recombination Landscape Evolution

My research focuses on the mechanisms of meiotic recombination, and the meiotic instability arising as a consequence. Meiotic recombination is responsible for breaking down linkage blocks and is the underlying process that generates and transmits biased gene conversion and minisatellite instability, as well as duplications and deletions. Despite being important drivers of genome evolution, little is known about the mechanisms and controlling factors of meiotic instability. We gain detailed insight into these mechanisms by determining de novo frequencies and the fine-scale distribution of meiotic instability events, using a combination of sophisticated germ-cell typing with whole-genome analyses.

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Dr. Linda Odenthal-Hesse

Max Planck Institute for Evolutionary Biology, Plön

Tel.: +49 (0) 4522-763-309
Email | homepage

Selected Publications

  • Odenthal-Hesse L, Berg IL, Veselis A, Jeffreys AJ, May CA (2014) Transmission Distortion Affecting Human Noncrossover but Not Crossover Recombination: A Hidden Source of Meiotic Drive. PLOS Genet 10(2):e1004106.
  • Berg IL, et al. (2011) Variants of the protein PRDM9 differentially regulate a set of human meiotic recombination hotspots highly active in African populations. PNAS 108(30):12378–12383.
  • Berg IL, et al. (2010) PRDM9 variation strongly influences recombination hot-spot activity and meiotic instability in humans. Nat Genet 42(10):859–863.