Evolutionary biology meets the antibiotic crisis

The current spread of antibiotic resistance poses a dramatic threat to global health. We are thus in urgent need of novel treatment strategies. As the evolutionary potential of pathogens is part of the problem, sustainable strategies should take account of the selection dynamics underlying the emergence and rise in resistance. However, most public health measures do not yet address pathogen evolution. The aim of the symposium and workshop is therefore to strengthen the exchange between fundamental research in evolutionary biology on antibiotic resistance and medical practice. How can medical challenges be approached by evolutionary biologists in a sensible way? And how can insights from evolutionary biology be implemented in practice? The workshop will therefore bring together physicians with expertise in antibiotic therapy, experimental evolutionary biologists, and modelers. The first part consists of a symposium with open registration (available spots limited to 20). In the second part, invited participants will form discussion groups to develop novel ideas concerning the above questions.



May 8-10, 2019


Max-Planck-Institute for Evolutionary Biology, Ploen


Dr. Hildegard Uecker              Dr. Camilo Barbosa



Preliminary Program

Wednesday, May 8th

  • 12:30 Get-together and welcome
    Evolutionary genetics of antimicrobial resistance
  • 13:00 Jens Rolff
    Resistance evolution against antimicrobial peptides
  • 13:30 Christoph Lange
    Precision Medicine prevents evolving drug resistance in M. tuberculosis
  • 14:00 Roland Regös
    Pharmacodynamic inoculum effect from the perspective of bacterial population modeling
  • 14:30 Annelies Zinkernagel
  • 15:00 Coffee break
  • 15:30 Hildegard Uecker
    Optimal antibiotic dosing: Insights from theory and experiments
  • 16:00 Uwe Rösler
    Antimicrobial Resistance at the animal-human-environment interface
  • 16:15 Marcus Fulde
  • 16:30 Ingrid Bobis
    Lessons from the Real World Scenario: Fighting Pseudomonas aeruginosa in Cystic Fibrosis (CF)
  • 17:00 Coffee break
  • 17:30 Anette Friedrichs
    Antibiotic treatment strategies and their clinical implementation
  • 18:00 Leif Tueffers
    Rapid in vivo resistance evolution during antibiotic therapy of Pseudomonas aeruginosa
  • 18:30 Aperitif

Thursday, May 9th

  • 9:00 Hinrich Schulenburg
    Sequential therapy as a strategy to minimize resistance evolution
  • 9:30 Jan Rupp
    Antibiotic cycling or mixing - is there a clinical way to avoid antimicrobial resistance?
  • 10:00 Alex Hall
    Resistance evolution of E. coli in populations and communities
  • 10:30 Coffee break
  • 11:00 Stefan Niemann
    Pathogen-based precision medicine for drug-resistant tuberculosis
  • 11:30 Annette Krenz-Weinreich
    Guideline-adapted diagnostics for cystic fibrosis patients
  • 12:00 Annette Moter
    How dead is dead in biofilms?
  • 12:30 Sebastian Bonhoeffer
    In vitro epidemiology: Comparison of cycling, mixing and combination therapy
  • 13:00 Lunch